ISSN 1662-4009 (online)

ey0018.3-12 | Clinical studies | ESPEYB18

3.12. Randomised trial of block and replace vs. dose titration thionamide in young people with thyrotoxicosis

CL Wood , M Cole , M Donaldson , DB Dunger , R Wood , N Morrison , JNS Matthews , SHS Pearce , TD Cheetham

Eur J Endocrinol. 2020;183:637–645. doi: 10.1530/EJE-20-0617.This study provides for the first time clear evidence that the block and replace (BR) strategy (combination of carbimazole plus levothyroxine) is not superior to the carbimazole dose titration (DT) strategy for treatment of paediatric Graves’ disease.Wood et al. present the first randomized c...